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Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy

We previously reported the in vitro selection and characterization of a DNA aptamer capable of stimulating remyelination in a mouse model of multiple sclerosis. This aptamer was selected for its ability to bind to suspensions of crude murine myelin in vitro. Our initial studies in vitro and in vivo...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Wilbanks, Brandon, Smestad, John, Heider, Robin M., Warrington, Arthur E., Rodriguez, Moses, Maher, L. James
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555174/
https://ncbi.nlm.nih.gov/pubmed/30855209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2018.0776
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