Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

INTRODUCTION: Fibrosis in human diseases and animal models is associated with aberrant Wnt/β-catenin pathway activation. The regulation, activity, mechanism of action and significance of Wnt/β-catenin signaling in the context of systemic sclerosis (SSc) has not been characterized. METHODS: Expressio...

Full description

Saved in:
Bibliographic Details
Main Authors: Wei, Jun, Fang, Feng, Lam, Anna P., Sargent, Jennifer L., Hamburg, Emily, Hinchcliff, Monique E., Gottardi, Cara J., Atit, Radhika, Whitfield, Michael L., Varga, John
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553791/
https://ncbi.nlm.nih.gov/pubmed/22328118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34424
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items