Inhaled Microparticles Containing Clofazimine Are Efficacious in Treatment of Experimental Tuberculosis in Mice

Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2....

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Hlavní autoři: Verma, Rahul Kumar, Germishuizen, Willem A., Motheo, M. Portia, Agrawal, Atul Kumar, Singh, Amit Kumar, Mohan, Mradul, Gupta, Pushpa, Gupta, Umesh Datta, Cholo, Moloko, Anderson, Ronald, Fourie, P. Bernard, Misra, Amit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553724/
https://ncbi.nlm.nih.gov/pubmed/23183441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01897-12
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