Inhaled Microparticles Containing Clofazimine Are Efficacious in Treatment of Experimental Tuberculosis in Mice

Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2....

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Detalhes bibliográficos
Main Authors: Verma, Rahul Kumar, Germishuizen, Willem A., Motheo, M. Portia, Agrawal, Atul Kumar, Singh, Amit Kumar, Mohan, Mradul, Gupta, Pushpa, Gupta, Umesh Datta, Cholo, Moloko, Anderson, Ronald, Fourie, P. Bernard, Misra, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553724/
https://ncbi.nlm.nih.gov/pubmed/23183441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01897-12
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