In Vitro Analysis of Albendazole Sulfoxide Enantiomers Shows that (+)-(R)-Albendazole Sulfoxide Is the Active Enantiomer against Taenia solium

Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with Taenia solium cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rate...

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Main Authors: Paredes, Adriana, de Campos Lourenço, Tiago, Marzal, Miguel, Rivera, Andrea, Dorny, Pierre, Mahanty, Siddhartha, Guerra-Giraldez, Cristina, García, Hector H., Nash, Theodore E., Cass, Quezia B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553705/
https://ncbi.nlm.nih.gov/pubmed/23229490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01465-12
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