In Vitro Analysis of Albendazole Sulfoxide Enantiomers Shows that (+)-(R)-Albendazole Sulfoxide Is the Active Enantiomer against Taenia solium

Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with Taenia solium cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rate...

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Detalhes bibliográficos
Main Authors: Paredes, Adriana, de Campos Lourenço, Tiago, Marzal, Miguel, Rivera, Andrea, Dorny, Pierre, Mahanty, Siddhartha, Guerra-Giraldez, Cristina, García, Hector H., Nash, Theodore E., Cass, Quezia B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553705/
https://ncbi.nlm.nih.gov/pubmed/23229490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01465-12
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