Alternative lengthening of telomeres in normal mammalian somatic cells

Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we generated a mouse strain containing a DNA tag in a single telomere. We found that the tagged telo...

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Détails bibliographiques
Auteurs principaux: Neumann, Axel A., Watson, Catherine M., Noble, Jane R., Pickett, Hilda A., Tam, Patrick P.L., Reddel, Roger R.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553280/
https://ncbi.nlm.nih.gov/pubmed/23307865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.205062.112
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