ATM impacts IGF-1 signaling in skeletal muscle

Reports that ataxia telangiectasia mutated (ATM) is required for full activation of Akt raise the hypothesis that ATM plays a role in IGF-1 signaling through the Akt/mTOR pathway. Differentiated C2C12 cells harboring either ATM-targeting shRNA or non-targeting shRNA and myotubes from a C2C12 lineage...

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Main Authors: Ching, James Kain, Luebbert, Stephen H., Collins, Roy L., Zhang, Zhihong, Marupudi, Nandhini, Banerjee, Sankha, Hurd, Robin D., Ralston, Lyle, Fisher, Jonathan S.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553258/
https://ncbi.nlm.nih.gov/pubmed/22941977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/expphysiol.2012.066357
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