Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development

Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extraction for endotoxin removal. Current vaccines use a...

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Dettagli Bibliografici
Autori principali: van de Waterbeemd, Bas, Zomer, Gijsbert, van den IJssel, Jan, van Keulen, Lonneke, Eppink, Michel H., van der Ley, Peter, van der Pol, Leo A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553081/
https://ncbi.nlm.nih.gov/pubmed/23372704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054314
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