Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development

Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extraction for endotoxin removal. Current vaccines use a...

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Detalhes bibliográficos
Main Authors: van de Waterbeemd, Bas, Zomer, Gijsbert, van den IJssel, Jan, van Keulen, Lonneke, Eppink, Michel H., van der Ley, Peter, van der Pol, Leo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553081/
https://ncbi.nlm.nih.gov/pubmed/23372704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054314
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