Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis; Implications for Vaccine Development

Outer membrane vesicles (OMV) contain immunogenic proteins and contribute to in vivo survival and virulence of bacterial pathogens. The first OMV vaccines successfully stopped Neisseria meningitidis serogroup B outbreaks but required detergent-extraction for endotoxin removal. Current vaccines use a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van de Waterbeemd, Bas, Zomer, Gijsbert, van den IJssel, Jan, van Keulen, Lonneke, Eppink, Michel H., van der Ley, Peter, van der Pol, Leo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553081/
https://ncbi.nlm.nih.gov/pubmed/23372704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054314
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