BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: Implications for breast cancer prevention with antioxidant therapies

Mutations in the BRCA1 tumor suppressor gene are commonly found in hereditary breast cancer. Similarly, downregulation of BRCA1 protein expression is observed in the majority of basal-like breast cancers. Here, we set out to study the effects of BRCA1 mutations on oxidative stress in the tumor micro...

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Detalhes bibliográficos
Main Authors: Martinez-Outschoorn, Ubaldo E., Balliet, Renee, Lin, Zhao, Whitaker-Menezes, Diana, Birbe, Ruth C., Bombonati, Alessandro, Pavlides, Stephanos, Lamb, Rebecca, Sneddon, Sharon, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552923/
https://ncbi.nlm.nih.gov/pubmed/23172369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22776
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