Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells

Ursolic acid (UA) is a pentacyclic triterpenoid with promising cancer chemopreventive properties. A better understanding of the mechanisms underlying anticancer activity of UA is needed for further development as a clinically useful chemopreventive agent. Here, we found that both endoplasmic reticul...

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Main Authors: Zhao, Chong, Yin, Shutao, Dong, Yinhui, Guo, Xiao, Fan, Lihong, Ye, Min, Hu, Hongbo
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Basic Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552883/
https://ncbi.nlm.nih.gov/pubmed/23182854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22805
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