Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between <5 and 15%. To address this medical need, we conducted a screen of a drug-like small molecule library for HCC-selective cytotoxins....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cuconati, Andrea, Mills, Courtney, Goddard, Cally, Zhang, Xianchao, Yu, Wenquan, Guo, Haitao, Xu, Xiaodong, Block, Timothy M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552860/
https://ncbi.nlm.nih.gov/pubmed/23355882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054595
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