Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between <5 and 15%. To address this medical need, we conducted a screen of a drug-like small molecule library for HCC-selective cytotoxins....

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Detalhes bibliográficos
Main Authors: Cuconati, Andrea, Mills, Courtney, Goddard, Cally, Zhang, Xianchao, Yu, Wenquan, Guo, Haitao, Xu, Xiaodong, Block, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552860/
https://ncbi.nlm.nih.gov/pubmed/23355882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054595
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