Influenza A Virus-Induced Early Activation of ERK and PI3K Mediates V-ATPase-Dependent Intracellular pH Change Required for Fusion

The vacuolar (H(+))-ATPases (V-ATPases) facilitate the release of influenza A virus (IAV) genome into the cytoplasm by acidifying the endosomal interior. The regulation of V-ATPases by signaling pathways has been demonstrated in various model systems. However, little is known about signaling-regulat...

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Main Authors: Marjuki, Henju, Gornitzky, Alex, Marathe, Bindumadhav M., Ilyushina, Natalia A., Aldridge, Jerry R., Desai, Gururao, Webby, Richard J., Webster, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552532/
https://ncbi.nlm.nih.gov/pubmed/21129142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2010.01556.x
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