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Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade

Influenza viruses replicate within the nucleus of infected cells. Viral genomic RNA, three polymerase subunits (PB2, PB1, and PA), and the nucleoprotein (NP) form ribonucleoprotein complexes (RNPs) that are exported from the nucleus late during the infectious cycle. The virus-induced Raf/MEK/ERK (MA...

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Autores principales: Marjuki, Henju, Yen, Hui-Ling, Franks, John, Webster, Robert G, Pleschka, Stephan, Hoffmann, Erich
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222635/
https://ncbi.nlm.nih.gov/pubmed/18053252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-134
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