Phosphorylation Modulates the Mechanical Stability of the Cardiac Myosin-Binding Protein C Motif

Cardiac myosin-binding protein C (cMyBP-C) is a thick-filament-associated protein that modulates cardiac contractility through interactions of its N-terminal immunoglobulin (Ig)-like C0-C2 domains with actin and/or myosin. These interactions are modified by the phosphorylation of at least four serin...

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Autors principals: Michalek, Arthur J., Howarth, Jack W., Gulick, James, Previs, Michael J., Robbins, Jeffrey, Rosevear, Paul R., Warshaw, David M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Molecular Machines, Motors, and Nanoscale Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552279/
https://ncbi.nlm.nih.gov/pubmed/23442866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.12.021
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