Structure and dynamics of a primordial catalytic fold generated by in vitro evolution

Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a non-catalytic protein scaffold, we recently generated a novel RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopte...

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Detalhes bibliográficos
Main Authors: Chao, Fa-An, Morelli, Aleardo, Haugner, John C., Churchfield, Lewis, Hagmann, Leonardo N., Shi, Lei, Masterson, Larry R., Sarangi, Ritimukta, Veglia, Gianluigi, Seelig, Burckhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552148/
https://ncbi.nlm.nih.gov/pubmed/23222886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1138
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