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EXTENDING FOLDAMER DESIGN BEYOND α-HELIX MIMICRY: α/β-PEPTIDE INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING
Diverse strategies have been explored to mimic the surface displayed by an α-helical segment of a protein, with the goal of creating inhibitors of helix-mediated protein-protein interactions. Many recognition surfaces on proteins, however, are topologically more complex and less regular than a singl...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3551614/ https://ncbi.nlm.nih.gov/pubmed/22548447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302469a |
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