FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress

Proper resolution of stalled replication forks is essential for genome stability. Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular single-stranded DNA (ssDNA)–binding protein complex. Compared with control cells, FBH1-d...

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Autori principali: Jeong, Yeon-Tae, Rossi, Mario, Cermak, Lukas, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Sung, Patrick, Schildkraut, Carl, Pagano, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2013
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549964/
https://ncbi.nlm.nih.gov/pubmed/23319600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201209002
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