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FBH1 protects melanocytes from transformation and is deregulated in melanomas
FBH1 is a member of the UvrD family of DNA helicases and plays a crucial role in the response to DNA replication stress. In particular, upon DNA replication stress, FBH1 promotes double-strand breakage and activation of the DNA-PK and ATM signaling cascades in a helicase-dependent manner. In the pre...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646868/ https://ncbi.nlm.nih.gov/pubmed/23466708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24165 |
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