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STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Cytosolic double-stranded DNA (dsDNA) triggers type-I interferon production through the endoplasmic reticulum adaptor protein STING (also known as MITA, MPYS and ERIS), which activates the transcription factor IRF3. However, how STING activates IRF3 remains largely unknown. Here we show that STING s...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549669/ https://ncbi.nlm.nih.gov/pubmed/22394562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002521 |
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