Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8(+) T-cell responses in melanoma patients

Optimal vaccine strategies must be identified for improving T-cell vaccination against infectious and malignant diseases. MelQbG10 is a virus-like nano-particle loaded with A-type CpG-oligonucleotides (CpG-ODN) and coupled to peptide(16–35) derived from Melan-A/MART-1. In this phase IIa clinical stu...

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Detalhes bibliográficos
Main Authors: Goldinger, Simone M, Dummer, Reinhard, Baumgaertner, Petra, Mihic-Probst, Daniela, Schwarz, Katrin, Hammann-Haenni, Anya, Willers, Joerg, Geldhof, Christine, Prior, John O, Kündig, Thomas M, Michielin, Olivier, Bachmann, Martin F, Speiser, Daniel E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549564/
https://ncbi.nlm.nih.gov/pubmed/22806397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142361
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