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Rhodium-Catalyzed Enantioselective Vinylogous Addition of Enol Ethers to Vinyldiazoacetates

A highly asymmetric vinylogous addition of acyclic silyl enol ethers to siloxyvinyldiazoacetate is described. The reaction features a diastereoselective 1,4-siloxy group migration event. Products are obtained in up to 97% ee. When more sterically crowded silyl enol ethers are employed, an enantiosel...

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Main Authors: Smith, Austin G., Davies, Huw M. L.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549400/
https://ncbi.nlm.nih.gov/pubmed/23098215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3092399
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