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Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability

Voltage-gated Na(+) channel (VGSC) β1 subunits, encoded by SCN1B, are multifunctional channel modulators and cell adhesion molecules (CAMs). Mutations in SCN1B are associated with the genetic epilepsy with febrile seizures plus (GEFS+) spectrum disorders in humans, and Scn1b-null mice display severe...

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Detalles Bibliográficos
Main Authors: Brackenbury, William J., Yuan, Yukun, O’Malley, Heather A., Parent, Jack M., Isom, Lori L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549092/
https://ncbi.nlm.nih.gov/pubmed/23277545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208767110
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