Scn1b deletion in adult mice results in seizures and SUDEP

Pathogenic loss‐of‐function variants in SCN1B are linked to Dravet syndrome (DS). Previous work suggested that neuronal pathfinding defects underlie epileptogenesis and SUDEP in the Scn1b null mouse model of DS. We tested this hypothesis by inducing Scn1b deletion in adult mice that had developed no...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: O'Malley, Heather A., Hull, Jacob M., Clawson, Brittany C., Chen, Chunling, Owens‐Fiestan, Gic, Jameson, Margaret B., Aton, Sara J., Parent, Jack M., Isom, Lori L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562025/
https://ncbi.nlm.nih.gov/pubmed/31211177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.785
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