Scn1b deletion in adult mice results in seizures and SUDEP

Pathogenic loss‐of‐function variants in SCN1B are linked to Dravet syndrome (DS). Previous work suggested that neuronal pathfinding defects underlie epileptogenesis and SUDEP in the Scn1b null mouse model of DS. We tested this hypothesis by inducing Scn1b deletion in adult mice that had developed no...

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Dettagli Bibliografici
Pubblicato in:Ann Clin Transl Neurol
Autori principali: O'Malley, Heather A., Hull, Jacob M., Clawson, Brittany C., Chen, Chunling, Owens‐Fiestan, Gic, Jameson, Margaret B., Aton, Sara J., Parent, Jack M., Isom, Lori L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562025/
https://ncbi.nlm.nih.gov/pubmed/31211177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.785
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