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Cellular toxicity of mutant SOD1 protein is linked to an easily soluble, non-aggregated form in vitro
Mutations in superoxide dismutase 1 (SOD1) are found in approximately 20% of patients with familial amyotrophic lateral sclerosis. The propensity of mutant SOD1 to form aggregates in pathologically affected cells (i.e. motor neurons) has implicated these poorly soluble protein aggregates and/or thei...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549044/ https://ncbi.nlm.nih.gov/pubmed/22926189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.010 |
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