Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma

Cancer associated fibroblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progression. CAF are `activated' and as such may be uniquely susceptible to apoptosis. Using cholangiocarcinoma (CCA) as a desmoplastic tumor model, we investigated the sensitivity of...

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Autores principales: Mertens, Joachim C., Fingas, Christian D., Christensen, John D., Smoot, Rory L., Bronk, Steven F., Werneburg, Nathan W., Gustafson, Michael P., Dietz, Allan B., Roberts, Lewis R., Sirica, Alphonse E., Gores, Gregory J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549008/
https://ncbi.nlm.nih.gov/pubmed/23221385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2130
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