Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma

Cancer associated fibroblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progression. CAF are `activated' and as such may be uniquely susceptible to apoptosis. Using cholangiocarcinoma (CCA) as a desmoplastic tumor model, we investigated the sensitivity of...

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Detalhes bibliográficos
Main Authors: Mertens, Joachim C., Fingas, Christian D., Christensen, John D., Smoot, Rory L., Bronk, Steven F., Werneburg, Nathan W., Gustafson, Michael P., Dietz, Allan B., Roberts, Lewis R., Sirica, Alphonse E., Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549008/
https://ncbi.nlm.nih.gov/pubmed/23221385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2130
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