Sorafenib Inhibits Signal Transducer and Activator of Transcription-3 Signaling in Cholangiocarcinoma Cells by Activating the Phosphatase Shatterproof 2

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is one of the key signaling cascades in cholangiocarcinoma (CCA) cells, mediating their resistance to apoptosis. Our aim was to ascertain if sorafenib, a multikinase inhibitor, may also inhibit JAK/STAT signaling an...

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Hlavní autoři: Blechacz, Boris R. A., Smoot, Rory L., Bronk, Steven F., Werneburg, Nathan W., Sirica, Alphonse E., Gores, Gregory J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891152/
https://ncbi.nlm.nih.gov/pubmed/19821497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23214
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