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Targeting PDGFR-β in Cholangiocarcinoma
BACKGROUND: Cholangiocarcinomas (CCAs) are highly desmoplastic neoplasms with a tumor microenvironment plentiful in myofibroblasts (MFBs). MFB-derived PDGF-BB survival signaling is a mediator of CCA cell resistance to apoptotic stimuli. This raises the concept that targeting PDGFR-β, a cognate recep...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274642/ https://ncbi.nlm.nih.gov/pubmed/22133064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1478-3231.2011.02687.x |
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