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Discrimination between CO and O(2) in heme oxygenase: Comparison of static structures and dynamic conformation changes following CO photolysis

Heme oxygenase (HO) catalyzes heme degradation, one of whose products is carbon monoxide (CO). It is well known that CO has a higher affinity for heme iron than does molecular oxygen (O(2)), therefore CO is potentially toxic. Because O(2) is required for the HO reaction, HO must discriminate effecti...

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Bibliografiske detaljer
Main Authors: Sugishima, Masakazu, Moffat, Keith, Noguchi, Masato
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548955/
https://ncbi.nlm.nih.gov/pubmed/23043644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301175x
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