Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene. If unaccounted for, this high degree of homology can cause serious...

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Autori principali: Flachsbart, Friederike, Möller, Michael, Däumer, Carolin, Gentschew, Liljana, Kleindorp, Rabea, Krawczak, Michael, Caliebe, Amke, Schreiber, Stefan, Nebel, Almut
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548564/
https://ncbi.nlm.nih.gov/pubmed/22588664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.83
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