Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals

Risk alleles for age-related diseases are expected to decrease in frequency in the population strata of increasing age. Consistent with this hypothesis, earlier studies showed a depletion of the Alzheimer's disease risk factor APOE(*)ɛ4 in long-lived individuals (LLIs). To evaluate whether this...

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Bibliographic Details
Main Authors: Flachsbart, Friederike, Caliebe, Amke, Nothnagel, Michael, Kleindorp, Rabea, Nikolaus, Susanna, Schreiber, Stefan, Nebel, Almut
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987169/
https://ncbi.nlm.nih.gov/pubmed/19639019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2009.136
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