Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery

Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), of which the cftr ΔF508 mutation is the most common. ΔF508 macrophages are intrinsically defective in autophagy because of the seque...

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Main Authors: Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Tazi, Mia, Hassan, Hoda, Zhang, Yucheng, Rowland, Patrick D., Malhotra, Sankalp, Aeffner, Famke, Davis, Ian C., Valvano, Miguel A., Amer, Amal O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548511/
https://ncbi.nlm.nih.gov/pubmed/23148214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411728
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