Minocycline Blocks Asthma-associated Inflammation in Part by Interfering with the T Cell Receptor-Nuclear Factor κB-GATA-3-IL-4 Axis without a Prominent Effect on Poly(ADP-ribose) Polymerase

Minocycline protects against asthma independently of its antibiotic function and was recently reported as a potent poly(ADP-ribose) polymerase (PARP) inhibitor. In an animal model of asthma, a single administration of minocycline conferred excellent protection against ovalbumin-induced airway eosino...

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Bibliographic Details
Main Authors: Naura, Amarjit S., Kim, Hogyoung, Ju, Jihang, Rodriguez, Paulo C., Jordan, Joaquin, Catling, Andrew D., Rezk, Bashir M., Elmageed, Zakaria Y. Abd, Pyakurel, Kusma, Tarhuni, Abdelmetalab F., Abughazleh, Mohammad Q., Errami, Youssef, Zerfaoui, Mourad, Ochoa, Augusto C., Boulares, A. Hamid
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548459/
https://ncbi.nlm.nih.gov/pubmed/23184953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.419580
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