Minocycline Blocks Asthma-associated Inflammation in Part by Interfering with the T Cell Receptor-Nuclear Factor κB-GATA-3-IL-4 Axis without a Prominent Effect on Poly(ADP-ribose) Polymerase

Minocycline protects against asthma independently of its antibiotic function and was recently reported as a potent poly(ADP-ribose) polymerase (PARP) inhibitor. In an animal model of asthma, a single administration of minocycline conferred excellent protection against ovalbumin-induced airway eosino...

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Detalhes bibliográficos
Main Authors: Naura, Amarjit S., Kim, Hogyoung, Ju, Jihang, Rodriguez, Paulo C., Jordan, Joaquin, Catling, Andrew D., Rezk, Bashir M., Elmageed, Zakaria Y. Abd, Pyakurel, Kusma, Tarhuni, Abdelmetalab F., Abughazleh, Mohammad Q., Errami, Youssef, Zerfaoui, Mourad, Ochoa, Augusto C., Boulares, A. Hamid
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548459/
https://ncbi.nlm.nih.gov/pubmed/23184953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.419580
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