Combined Inhibition of mTORC1 and mTORC2 Signaling Pathways Is a Promising Therapeutic Option in Inhibiting Pheochromocytoma Tumor Growth: In Vitro and In Vivo Studies in Female Athymic Nude Mice

Several lines of evidence, including the recent discovery of novel susceptibility genes, point out an important role for the mammalian target of rapamycin (mTOR) signaling pathway in the development of pheochromocytoma. Analyzing a set of pheochromocytomas from patients with different genetic backgr...

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Detalhes bibliográficos
Main Authors: Giubellino, Alessio, Bullova, Petra, Nölting, Svenja, Turkova, Hana, Powers, James F., Liu, Qingsong, Guichard, Sylvie, Tischler, Arthur S., Grossman, Ashley B., Pacak, Karel
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Cancer-Oncogenes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548182/
https://ncbi.nlm.nih.gov/pubmed/23307788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1854
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