Phytoestrogen Genistein Protects Against Endothelial Barrier Dysfunction in Vascular Endothelial Cells Through PKA-Mediated Suppression of RhoA Signaling

The soy-derived phytoestrogen genistein has received attention for its potential to improve vascular function, but its mechanism remains unclear. Here, we report that genistein at physiologically relevant concentrations (0.1–10 μM) significantly inhibited thrombin-induced increase in endothelial mon...

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Bibliografiska uppgifter
Huvudupphovsmän: Jia, Zhenquan, Zhen, Wei, Velayutham Anandh Babu, Pon, Liu, Dongmin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2013
Ämnen:
General Endocrinology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548180/
https://ncbi.nlm.nih.gov/pubmed/23254196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1774
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