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Phytoestrogen Genistein Protects Against Endothelial Barrier Dysfunction in Vascular Endothelial Cells Through PKA-Mediated Suppression of RhoA Signaling
The soy-derived phytoestrogen genistein has received attention for its potential to improve vascular function, but its mechanism remains unclear. Here, we report that genistein at physiologically relevant concentrations (0.1–10 μM) significantly inhibited thrombin-induced increase in endothelial mon...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Endocrine Society
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548180/ https://ncbi.nlm.nih.gov/pubmed/23254196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1774 |
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