Macrophages activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression

OBJECTIVE: Factors and mechanisms that activate macrophages in atherosclerotic plaques are incompletely understood. We examined the capacity of heparanase to activate macrophages. RESULTS/METHODS: Highly purified heparanase was added to mouse peritoneal macrophages (MPM) and macrophage-like J774 cel...

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Bibliografiske detaljer
Main Authors: Blich, Miry, Golan, Amnon, Arvatz, Gil, Sebbag, Anat, Shafat, Itay, Sabo, Edmond, Cohen-Kaplan, Victoria, Petcherski, Sirouch, Avniel-Polak, Shani, Eitan, Amnon, Hammerman, Haim, Aronson, Doron, Axelman, Elena, Ilan, Neta, Nussbaum, Gabriel, Vlodavsky, Israel
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548034/
https://ncbi.nlm.nih.gov/pubmed/23162016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.254961
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