A novel conotoxin, qc16a, with a unique cysteine framework and folding

A novel conotoxin, qc16a, was identified from the venom of vermivorous Conus quercinus. qc16a has only 11 amino acid residues, DCQPCGHNVCC, with a unique cysteine pattern. Its disulfide connectivity was determined to be I–IV, II–III. The NMR structure shows that qc16a adopts a ribbon conformation wi...

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Main Authors: Ye, Mingyu, Hong, Jing, Zhou, Mi, Huang, Lijun, Shao, Xiaoxia, Yang, Youshan, Sigworth, Fred J., Chi, Chengwu, Lin, Donghai, Wang, Chunguang
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547678/
https://ncbi.nlm.nih.gov/pubmed/21524672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2011.04.008
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