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miRNA Gene Promoters Are Frequent Targets of Aberrant DNA Methylation in Human Breast Cancer

miRNAs are important regulators of gene expression that are frequently deregulated in cancer, with aberrant DNA methylation being an epigenetic mechanism involved in this process. We previously identified miRNA promoter regions active in normal mammary cell types and here we analyzed which of these...

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Hlavní autoři: Vrba, Lukas, Muñoz-Rodríguez, José L., Stampfer, Martha R., Futscher, Bernard W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547033/
https://ncbi.nlm.nih.gov/pubmed/23342147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054398
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