Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis

Mammalian reovirus is a benign virus that possesses the natural ability to preferentially infect and kill cancer cells (reovirus oncolysis). Reovirus exploits aberrant Ras signalling in many human cancers to promote its own replication and spread. In vitro and in vivo studies using reovirus either s...

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Autores principales: Pan, Da, Marcato, Paola, Ahn, Dae-Gyun, Gujar, Shashi, Pan, Lu-Zhe, Shmulevitz, Maya, Lee, Patrick W. K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546971/
https://ncbi.nlm.nih.gov/pubmed/23342061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054006
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