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Reovirus Variants with Mutations in Genome Segments S1 and L2 Exhibit Enhanced Virion Infectivity and Superior Oncolysis

Reovirus preferentially replicates in transformed cells and is being explored as a cancer therapy. Immunological and physical barriers to virotherapy inspired a quest for reovirus variants with enhanced oncolytic potency. Using a classical genetics approach, we isolated two reovirus variants (T3v1 a...

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Detalhes bibliográficos
Principais autores: Shmulevitz, Maya, Gujar, Shashi A., Ahn, Dae-Gyun, Mohamed, Adil, Lee, Patrick W. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416329/
https://ncbi.nlm.nih.gov/pubmed/22532697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00304-12
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