Reduction of Virion-Associated σ1 Fibers on Oncolytic Reovirus Variants Promotes Adaptation toward Tumorigenic Cells

Wild-type mammalian orthoreovirus serotype 3 Dearing (T3wt) is nonpathogenic in humans but preferentially infects and kills cancer cells in culture and demonstrates promising antitumor activity in vivo. Using forward genetics, we previously isolated two variants of reovirus, T3v1 and T3v2, with incr...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Mohamed, Adil, Teicher, Carmit, Haefliger, Sarah, Shmulevitz, Maya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442378/
https://ncbi.nlm.nih.gov/pubmed/25653434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03651-14
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