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Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

BACKGROUND: The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate for its protein kinase activity is its regulatory subunit, p85α, which becomes phosphorylated on Serine 608. Phospho...

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Hlavní autoři: Layton, Meredith J, Saad, Mirette, Church, Nicole L, Pearson, Richard B, Mitchell, Christina A, Phillips, Wayne A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546864/
https://ncbi.nlm.nih.gov/pubmed/23270540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-13-30
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