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Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph

BACKGROUND: Our previous studies suggest silkworms can be used as model animals instead of mammals in pharmacologic studies to develop novel therapeutic medicines. We examined the usefulness of the silkworm larvae Bombyx mori as an animal model for evaluating tissue injury induced by various cytotox...

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Detalhes bibliográficos
Main Authors: Inagaki, Yoshinori, Matsumoto, Yasuhiko, Kataoka, Keiko, Matsuhashi, Naoya, Sekimizu, Kazuhisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545979/
https://ncbi.nlm.nih.gov/pubmed/23137391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-13-13
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