Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

BACKGROUND: Peripheral nerve injuries often trigger a hypersensitivity to tactile stimulation. Behavioural studies demonstrated efficient and side effect-free analgesia mediated by opioid receptors on peripheral sensory neurons. However, mechanistic approaches addressing such opioid properties in pa...

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Main Authors: Schmidt, Yvonne, Labuz, Dominika, Heppenstall, Paul A, Machelska, Halina
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545910/
https://ncbi.nlm.nih.gov/pubmed/23116256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-81
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